Syrian Rue or Peganum harmala has been used as an entheogen in the Middle East, and in modern Western culture, it is often used as an analogue of Banisteriopsis caapi to create an ad hoc Ayahuasca, the South American mixture of phytoindoles including DMT with β-carbolines. However, Syrian rue has distinct aspects from caapi and a unique entheogenic signature. Some scholars identify Harmal with the entheogenic haoma of pre-Zoroastrian Persian religions.
A red dye, "Turkey Red," from the seeds is often used in Western Asia to dye carpets. It is also used to dye wool. When the seeds are extracted with water, a yellow fluorescent dye is obtained. If they are extracted with alcohol, a red dye is obtained. The stems, roots and seeds can be used to make inks, stains and tattoos.